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OALib Journal期刊

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EVALUATION OF THE EFFECTS OF CHLOROQUINE PHOSPHATE EYE DROPS IN PATIENTS WITH DRY EYE SYNDROME
Ankita S. Bhavsar,Samir G. Bhavsar,Sunita M. Jain
International Journal of Biomedical and Advance Research , 2011, DOI: 10.7439/ijbar.v2i6.34
Abstract: Objectives: To evaluate the efficacy and safety of 0.03% chloroquine phosphate eye drops in comparison with artificial tears for the treatment of dry eye syndrome. Methods: Total 170 patients (121 female, 49 male) were enrolled in prospective, randomized, open label case-controlled study. Patients (mean age 53.4 ± 10.5 years) were randomly assigned in to 2 different treatment groups. i.e. Group: 1 Carboxymethyl Cellulose (CMC), 85 patients, Dose: 0.5%, 2-4 times / day; Group: 2 Chloroquine phosphate (CHQ), 85 patients, Dose: 0.03%, twice a day. Main outcome measures included efficacy aspects viz. Lissamine Green Stain Score (LGSS), Fluorescine Stain Score (FLSS), Schirmer test, and Ocular Surface Disease Index (OSDI) - a measure of symptom frequency and impact on vision related functioning, and safety aspects such as vital signs, intraocular pressure, visual acuity, color vision and monitoring of adverse events. Results: The most significant improvements with CHQ treatment were in LGSS from baseline (2.79 ±0.12) to (0.22 ±0.04) after treatment (p < 0.001) with the net change -2.57 (95% CI of -2.83 to -2.32). CHQ treated group also reflected significant reduction in FLSS at final visit (0.47 ±0.065) as compared to baseline (3.21 ±0.12) with a net change of -2.74 (95% CI of -3.007 to -2.451). Significant decrease in OSDI scores indicated a decrease in the effect of ocular symptoms on patientsa€ daily lives. Conclusions: CHQ eye drops were found to be more effective, safe and well tolerated than artificial tears in patients with dry eye syndrome.
Optimization of Cultural Conditions for the Production of Antibiotic by Streptomyces sp. VRY-1
Richa Jain, Kamal Uddin Zaidi, Naima Parveen, Ankita Saxena
Recent Research in Science and Technology ,
Abstract: Streptomyces sp. VRY-1 was screened for its bioactive potentials against various pathogenic microorganisms and was found to possess antibacterial activity against Salmonella typhimurium (drug resistant strain of bacteria) and various other pathogenic bacteria and fungi. Optimization of cultural conditions for production of antibiotic showed that maximum antibiotic production occurred on 10th day in stationary cultural, 28？？ C, 8.0 pH, liver extract, 1.5%(w/v) glucose. The bioactive compound was found to be soluble in water and ethyl acetate.
Stochastic Mode-Reduction in Models with Conservative Fast Sub-Systems
Ankita Jain,Ilya Timofeyev,Eric Vanden-Eijnden
Mathematics , 2014,
Abstract: A stochastic mode reduction strategy is applied to multiscale models with a deterministic energy-conserving fast sub-system. Specifically, we consider situations where the slow variables are driven stochastically and interact with the fast sub-system in an energy-conserving fashion. Since the stochastic terms only affect the slow variables, the fast-subsystem evolves deterministically on a sphere of constant energy. However, in the full model the radius of the sphere slowly changes due to the coupling between the slow and fast dynamics. Therefore, the energy of the fast sub-system becomes an additional hidden slow variable that must be accounted for in order to apply the stochastic mode reduction technique to systems of this type.
Metal selective co-ordinative self-assembly of e？？？-donors
Ankit Jain,Ankita Goswami,K Venkata Rao,Subi J George
- , 2011,
Abstract:
Epidemiology of EGFR Mutation in Adenocarcinoma NSCLC Patients in India: A Systematic Review and Meta-Analysis  [PDF]
Ankita Jain, Kumar Prabhash, Venkatraman Radhakrishnan, Shashank Srinivasan
Advances in Lung Cancer (ALC) , 2024, DOI: 10.4236/alc.2024.131001
Abstract: Studies reporting the Indian prevalence of Epidermal Growth Factor Receptor (EGFR) mutation are mostly single centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence of EGFR mutation epidemiology in Indian patients with adenocarcinoma (ADC) Non-Small Cell Lung Cancer (NSCLC). We conducted a structured literature search in PubMed, and EMBASE databases from January 2004 through October 2019. The primary outcome of interest was prevalence of EGFR mutation by gender, smoking status, and mutation subtype. The review included 34 studies. EGFR mutation prevalence was 39.5% in patients with ADC, and significantly higher in females, non-smokers, and patients with exon 19 deletions. The EGFR mutation frequency in Indian patients with ADC was higher than reported in Caucasians but at a lower range of that reported in East Asians. These findings support the use of EGFR mutation testing to guide choice of treatment.
A LINEAR QSAR AND DOCKING APPROACH TO MODEL INHIBITORY ACTIVITY OF 2-ARYLBENZOXAZOLE DERIVATIVES AS CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITORS
MUKESH YADAV, ANURAJ NAYARISSERI, SHOBHA JOSHI, ANKITA GUPTA, PURVA HOLKAR, ASHISH RAJPUT, RISHABH JAIN
International Journal of Drug Discovery , 2011,
Abstract: QSAR studies of thirty 2-arylbenzoxazole derivatives are carried out to probe their inhibitory activityagainst Cholesteryl Ester Transfer Protein (CETP). QSAR models have been obtained using multiple linearregression (MLR) analysis after manifestation of forward selection algorithm to cull significant descriptors out ofdescriptor’s pool. QSAR models are elected with adherent set of statistical parameters with R2=0.9431 andR2=0.9069. Validation of modeling includes method of Y-Scrambling and in addition to this, some other methodsof validation. Moreover, QSAR approach of 2-arylbenzoxazoles are also attempted, supported and validated byflexible docking studies as well. The search strategies include evolutionary algorithm and edited form of GehlhaarPLP scoring function. The same set of thirty candidates from 2-arylbenzoxazole derivatives is processed inmolecular docking and their docking scores are found in agreement with QSAR studies reported. RemarkableCETP inhibitory activity is exhibited by a 2-arylbenzoxazole derivatives molecule 29C with most comprehensiveset of interactions with rerank scores -102.167 and RMSD values 1.104. Hydrogen bond interactions along withhydrophobic and electrostatic interactions are mapped to confirm their potencies.
Feasibility of Ocean Acoustic Waveguide Remote Sensing (OAWRS) of Atlantic Cod with Seafloor Scattering Limitations
Ankita D. Jain,Anamaria Ignisca,Dong Hoon Yi,Purnima Ratilal,Nicholas C. Makris
Remote Sensing , 2014, DOI: 10.3390/rs6010180
Abstract: Recently reported declines in the population of Atlantic cod have led to calls for additional survey methods for stock assessments. In combination with conventional line-transect methods that may have ambiguities in sampling fish populations, Ocean Acoustic Waveguide Remote Sensing (OAWRS) has been shown to have a potential for providing accurate stock assessments (Makris N.C., et al. Science 2009, 323, 1,734–1,737; 54th Northeast Regional Stock Assessment Workshop (54th SAW) US Department of Commerce, Northeast Fisheries Science Center, 2012). The use of OAWRS technology enables instantaneous wide-area sensing of fish aggregations over thousands of square kilometers. The ratio of the intensity of scattered returns from fish versus the seafloor in any resolution cell typically determines the maximum fish detection range of OAWRS, which then is a function of fish population density, scattering amplitude and depth distribution, as well as the level of seafloor scattering. With the knowledge of oceanographic parameters, such as bathymetry, sound speed structure and attenuation, we find that a Rayleigh–Born volume scattering approach can be used to efficiently and accurately estimate seafloor scattering over wide areas. From hundreds of OAWRS measurements of seafloor scattering, we determine the Rayleigh–Born scattering amplitude of the seafloor, which we find has a ？ 2,4 frequency dependence below roughly 2 kHz in typical continental shelf environments along the US northeast coast. We then find that it is possible to robustly detect cod aggregations across frequencies at and near swim bladder resonance for observed spawningconfigurations along the U.S. northeast coast, roughly the two octave range 150–600 Hzfor water depths up to roughly 100 m. This frequency range is also optimal for long-rangeocean acoustic waveguide propagation, because it enables multimodal acoustic waveguidepropagation with minimal acoustic absorption and forward scattering losses. As the sensingfrequency moves away from the resonance peak, OAWRS detection of cod becomesincreasingly less optimal, due to a rapid decrease in cod scattering amplitude. In otherenvironments where cod depth may be greater, the optimal frequencies for cod detectionare expected to increase with swim bladder resonance frequency.
Medical School and Stress: A Cross-sectional Study of Stress among Medical Students in Uttar Pradesh University of Medical Sciences in district Etawah
Ankita Sharma,Jyoti Mehra,Kiran Krishnappa,Kripa Shankar Nayak,Naresh Pal Singh,Pankaj Kumar Jain
- , 2018,
Abstract: Background: Medical education has come long way since the era of Hippocrates. It is progressively evolving into a more organized and complicated system. All over the world, Medical education is criticized as one of the most demanding and stressful academics, showing effects on physical and mental health of medical students. This research was conducted to study stress and its factors in students of UPUMS, Saifai, Etawah, Uttar Pradesh. Aim & Objectives: To estimate the prevalence of stress among medical students of UPUMS. To estimate internal consistency of Medical Students Stress Questionnaire (MSSQ-40). Material & Methods: A Cross-sectional study was carried out during Oct. 2017 - Mar. 2018 among MBBS Students of all academic years in Uttar Pradesh University of Medical Sciences (UPUMS), Saifai. All the students enrolled in the university available on the day of data collection were recruited in the study. MSSQ-40 was the study tool to assess stress. Ethical clearance was obtained from Ethical Committee. Statistical analysis done in SPSS-23. Results: The mean age of subjects was 22.4±2.3 years, more than 84% of the respondents had moderate and high stress. More number of females perceived stress than the male, 33% female were suffering from high & severe stress. statistically significant. Conclusion: Gender & grades had clear association with stress, academics & interpersonal relation caused more stress. Early detection and effective intervention can prevent future illness among medical students
Versatile Voltage-Mode Universal Filter Using Differential Difference Current Conveyor  [PDF]
Sudhanshu Maheshwari, Ankita Gangwar
Circuits and Systems (CS) , 2011, DOI: 10.4236/cs.2011.23030
Abstract: A novel four-input three-output voltage-mode differential difference current conveyor (DDCC) based universal filter is presented. The circuit uses three DDCCs as active elements, two resistors and two capacitors as passive elements. The circuit along with its versatility enjoys the advantage of minimum number of passive elements employment. SPICE simulation results are given to confirm the theoretical analysis. The proposed circuit is a novel addition to the existing knowledge on the subject.
Kinetic Studies on Hexavalent Chromium Reduction  [PDF]
Ankita Basu, Bidyut Saha
American Journal of Analytical Chemistry (AJAC) , 2010, DOI: 10.4236/ajac.2010.11003
Abstract: r(VI) is a known human carcinogen. It is a wide spread environmental contaminant as it is extensively used in different industry. The kinetic study of reduction of Cr(VI) by a known organic substance, 1-butanol in micellar media have been studied spectrophotometrically. The reduction of Cr(VI) to Cr(III) occurs in a micro- heterogeneous system in cell cytoplasm. As micelles are considered to mimic the cellular membranes, the reduction process occurring in the micellar system is considered as a model to obtain insight in to the reduction process prevailing in body systems. Micellar media is also a probe to establish the mechanistic paths of reduction of Cr(VI) to Cr(III) and the effects of some electrolytes common to a biological systems are studied to establish the proposed reaction mechanism strongly. The overall reaction follows a first order dependency on substrate and hexavalent chromium and second order dependency on hydrogen ion. Suitable surfactant & suitable concentration of electrolyte enhance the rate of the reaction.
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